Glass frogs are appropriately named for the transparent skin on their belly, making their organs visible. Fleischmanns Glass Frog, also known as the Northern Glass Frog, is a small, delicate frog, 2-3.2 cm in length, with light green skin with yellow spots and fine black flecks. It has a short, rounded snout and gold irises with horizontal, elliptical pupils, and its eyes point forward. It has small suction pads on its toes. In addition to its distinctive upper side, it can be best identified by its underside, in which a white sheet of guanine covers its heart, upper liver and also wraps around its digestive system. Different species of glass frogs have different organs visible.

Fleischmanns Glass Frog is found in the humid lowland, montane and subtropical forests from Mexico to northwestern South America. It is one of the most widespread species of glass frogs. It can be found in shrubs and trees along forest streams; it requires good vegetation growth, and is found in primary and secondary growth forest. It is nocturnal and arboreal. During the day these frogs hide on the underside of leaves. At night, they emerge to feed and males search for mates. They eat flies, spiders and other small invertebrates.